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Vaccination key to ‘Super Immunity’ Against COVID-19,

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TUESDAY, January 25, 2022 (HealthDay News). Coronavirus infections that occur before and after vaccination produce equal levels of immunity. Researchers report that vaccinating is the key to this so-called “super immunity.”

“It makes no difference whether you get infected-and-then-vaccinated or a vaccinated-and-then-a-breakthrough infection,” said study co-senior author Fikadu Tafesse. He is an assistant professor of molecular immunology and microbiology at the Oregon Health & Science University School of Medicine in Portland.

Tafesse stated in a university press release that “in either case, you will get an extremely, really robust immune reaction — amazingly high.”

Study participants included 104 university employees who had received the Pfizer vaccine. Forty-two people had never been infected, and 31 were infected before vaccination. Thirty-one of these were also infected with breakthrough infections.

Three variants of the SARS CoV-2 virus were given to blood samples taken from participants. The results showed that those who were infected had stronger immunity than those who weren’t.

Notably, blood from those infected and vaccinated (hybrid immunity) contained equally high levels of antibodies and was at least 1,000% more efficient than blood from those who had never been infected.

Although the study was done before the Omicron variant became highly transmissible, the authors believe that the hybrid immune response to the Omicron variant would be the same.

The defense stated that developing breakthrough infections is high due to the abundance of viruses in our environment. “But getting vaccinated is a better way to protect ourselves. We’ll have super immunity if the virus strikes.

These findings were published online in Science Immunology on January 25, 2015.

“I would anticipate at this point many vaccinated persons will wind up with breakthrough infected — and thus a form of hybrid immunity,” Dr. Bill Messer (study senior co-author), an assistant professor of molecular biology and immunology and medicine at OHSU.

Messer says that Omicron is still raging, and many people who have been infected previously will be infected again. They will likely experience a more variable immune response to the vaccine than those vaccinated.

Vaccination increases the likelihood of an immune response. He said, “I cannot guarantee such immunity will vary, with some people receiving equivalent immunity to vaccination, but most won’t.” “And it is impossible to determine who gets what immunity without laboratory testing.”

Another member of the research group agreed.

Natural infection is not the only factor that can affect immunity. “Some people have a strong response while others don’t,” Dr. Marcel Curlin (study senior co-author), an associate professor of medicine infectious diseases at OHSU and director OHSU Occupational Health. “But, vaccination and immunity from infection almost always produce extreme responses.”

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